Endocrine Abstracts

Podoplanin (PDPN), a mucine type transmembrane glycoprotein specific to lymphatic system is expressed in a variety of human tumors and regarded as a factor promoting tumor progression. In a recent work, we found PDPN expression in tumor cells of 40% of papillary thyroid carcinomas (PTC), however it role remains unclear. The purpose of this study was to elucidate the molecular role of PDPN in the biology of thyroid cancer cells.PDPN gene and prot...

Introduction: The differentiated thyroid cancer (DTC) is the most frequent endocrine malignancy with the incidence increasing worldwide. Although, DTCs are considered to be mostly indolent lesions, the proportion of patients develop metastases. Therefore, identification of molecular factors that are involved in thyroid tumour progression might help to better understand the mechanism of thyroid cancer metastasis. In the present study we examine the role of the transcription fac...